Summary:

NameHepatocellular carcinoma (A:m6A)
DescriptionSnail, a key transcription factor of EMT, has an increased m6A methylation in its CDS and 3′UTR regions, through METTL3. m6A in CDS of Snail can trigger its translation elongation via interaction with YTHDF1 and eEF-2.
Related RNA reactionA:m6A
Found in RNAmRNA
Modified TranscriptSnail
Mapping TechnologyMeRIP-seq
Quantification techniquesMeRIP-qPCR, m6A dot blot assay

Enzymes connected to this disease:

Acronym Full name Enzyme Role Organism
METTL3 N6-adenosine-methyltransferase 70 kDa subunit oncogene Homo sapiens
 

Publications:

ID Title Authors Journal Details PubMed Id DOI
1039 RNA mA methylation regulates the epithelial mesenchymal transition of cancer cells and translation of Snail. Xinyao Lin Nat Commun [details] 31061416 10.1038/s41467-019-09865-9

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