Summary:

NameHepatocellular carcinoma (A:m6A)
DescriptionIncreased m6A methylation level is associated to a decreased HCC cells proliferation. miR145 targets YTHDF2 3'UTR region and reduces its expression. The reduced expression of YTHDF2 is associated to an increased m6A level in the cells. In HCC cells there is a downregulation of miR145, an increased expression of YTHDF2 which recognize mRNA m6A sites and mediates mRNA degradation (decrease of m6A levels)
Related RNA reactionA:m6A
Modified Transcript
Mapping Technology
Quantification techniques

Enzymes connected to this disease:

Acronym Full name Enzyme Role Organism
YTHDF2 YTH N6-methyladenosine RNA binding protein 2 oncogene Homo sapiens
 

Publications:

ID Title Authors Journal Details PubMed Id DOI
1041 MicroRNA-145 Modulates -Methyladenosine Levels by Targeting the 3'-Untranslated mRNA Region of the -Methyladenosine Binding YTH Domain Family 2 Protein. Zhe Yang J Biol Chem [details] 28104805 10.1074/jbc.M116.749689

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