Summary:

NameHepatocellular carcinoma (A:m6A)
Descriptionm6A methylation level decreases the expression of tumor suppressor genes like SOCS2. The upregulation of METTL3 in HCC mediates this event through an m6A-YTHDF2-dependent mechanism and increases cancer cells proliferation, migration and metastasis formation
Related RNA reactionA:m6A
Found in RNAmRNA
Modified TranscriptSOCS2
Mapping TechnologyMeRIP-seq
Quantification techniquesMeRIP-qPCR

Enzymes connected to this disease:

Acronym Full name Enzyme Role Organism
YTHDF2 YTH N6-methyladenosine RNA binding protein 2 oncogene Homo sapiens
 

Publications:

ID Title Authors Journal Details PubMed Id DOI
1037 RNA N6-methyladenosine methyltransferase-like 3 promotes liver cancer progression through YTHDF2-dependent posttranscriptional silencing of SOCS2. Mengnuo Chen Hepatology [details] 29171881 10.1002/hep.29683

Copyright © Genesilico - All rights reserved
If you have any advice or suggestions for corrections or improvements, please contact: Andrea Cappannini - lp.vog.bcmii@ininnappaca