| Name | Hepatocellular carcinoma (A:m6A) |
| Description | HCC exhibited a characteristic gain of m6A modification in tandem with an increase of mRNA expression, owing to YTHDF2 reduction. YTHDF2 deficiency leads to mRNA stabilization of IL-11 and Serpin E2, the key mediators in support of hypoxia-induced cancer cell survival and vascular reconstruction. YTHDF2 is inhibited by HIF- 2α |
| Related RNA reaction | A:m6A |
| Found in RNA | mRNA |
| Modified Transcript | IL-11 and SERPINE2 |
| Mapping Technology | MeRIP-seq |
| Quantification techniques | LC-MS/MS, MeRIP-qPCR |
| Acronym | Full name | Enzyme Role | Organism | Comment |
|---|---|---|---|---|
| YTHDF2 | YTH N6-methyladenosine RNA binding protein 2 | tumor-suppressor | Homo sapiens |
| ID | Title | Authors | Journal | Details | ||
|---|---|---|---|---|---|---|
| 1042 | YTHDF2 reduction fuels inflammation and vascular abnormalization in hepatocellular carcinoma. | He Zhang,Jun Liu,Zhenjun Zhao,Jianye Wang,Zhike Lu,Bian Hu,Jiankui Zhou,Zhicong Zhao,Mingxuan Feng,Haiyan Zhang,Bin Shen,Xingxu Huang,Beicheng Sun,Mark J Smyth,Chuan He, | Mol Cancer | [details] | 31735169 | 10.1186/s12943-019-1082-3 |