NameHepatocellular carcinoma (A:m6A)
DescriptionHCC exhibited a characteristic gain of m6A modification in tandem with an increase of mRNA expression, owing to YTHDF2 reduction. YTHDF2 deficiency leads to mRNA stabilization of IL-11 and Serpin E2, the key mediators in support of hypoxia-induced cancer cell survival and vascular reconstruction. YTHDF2 is inhibited by HIF- 2α
Related RNA reactionA:m6A
Found in RNAmRNA
Modified TranscriptIL-11 and SERPINE2
Mapping TechnologyMeRIP-seq
Quantification techniquesLC-MS/MS, MeRIP-qPCR

Enzymes connected to this disease:

Acronym Full name Enzyme Role Organism
YTHDF2 YTH N6-methyladenosine RNA binding protein 2 tumor-suppressor Homo sapiens


ID Title Authors Journal Details PubMed Id DOI
1042 YTHDF2 reduction fuels inflammation and vascular abnormalization in hepatocellular carcinoma. Jiajie Hou Mol Cancer [details] 31735169 10.1186/s12943-019-1082-3

Copyright © Genesilico - All rights reserved
If you have any advice or suggestions for corrections or improvements, please contact: Andrea Cappannini - lp.vog.bcmii@ininnappaca