|Hepatocellular carcinoma (A:m6A)
|HCC exhibited a characteristic gain of m6A modification in tandem with an increase of mRNA expression, owing to YTHDF2 reduction. YTHDF2 deficiency leads to mRNA stabilization of IL-11 and Serpin E2, the key mediators in support of hypoxia-induced cancer cell survival and vascular reconstruction. YTHDF2 is inhibited by HIF- 2α
|Related RNA reaction
|Found in RNA
|IL-11 and SERPINE2
|YTH N6-methyladenosine RNA binding protein 2
|YTHDF2 reduction fuels inflammation and vascular abnormalization in hepatocellular carcinoma.