Summary:

NameHepatocellular carcinoma (A:m6A)
DescriptionHCC exhibited a characteristic gain of m6A modification in tandem with an increase of mRNA expression, owing to YTHDF2 reduction. YTHDF2 deficiency leads to mRNA stabilization of IL-11 and Serpin E2, the key mediators in support of hypoxia-induced cancer cell survival and vascular reconstruction. YTHDF2 is inhibited by HIF- 2α
Related RNA reactionA:m6A
Found in RNAmRNA
Modified TranscriptIL-11 and SERPINE2
Mapping TechnologyMeRIP-seq
Quantification techniquesLC-MS/MS, MeRIP-qPCR

Enzymes connected to this disease:

Acronym Full name Enzyme Role Organism
YTHDF2 YTH N6-methyladenosine RNA binding protein 2 tumor-suppressor Homo sapiens
 

Publications:

ID Title Authors Journal Details PubMed Id DOI
1042 YTHDF2 reduction fuels inflammation and vascular abnormalization in hepatocellular carcinoma. Jiajie Hou Mol Cancer [details] 31735169 10.1186/s12943-019-1082-3

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