| Name | Hepatocellular carcinoma (A:m6A) |
| Description | YTHDF2 was specifically down-regulated by hypoxia in HCC cells, and that YTHDF2 may function as a tumor suppressor in HCC by negatively modulating the EGFR mRNA stability via its binding the m6A site in the EGFR 3’UTR of mRNA, which in turn impairs the MEK/ERK pathway and consequently impedes the cell proliferation and growth |
| Related RNA reaction | A:m6A |
| Found in RNA | mRNA |
| Modified Transcript | EGFR |
| Mapping Technology | |
| Quantification techniques |
| Acronym | Full name | Enzyme Role | Organism | Comment |
|---|---|---|---|---|
| YTHDF2 | YTH N6-methyladenosine RNA binding protein 2 | tumor-suppressor | Homo sapiens |
| ID | Title | Authors | Journal | Details | ||
|---|---|---|---|---|---|---|
| 1043 | YTHDF2 suppresses cell proliferation and growth via destabilizing the EGFR mRNA inhepatocellular carcinoma. | Zhong L | Cancer Lett | [details] | 30423408 | S0304-3835(18)30670-0 |