Summary:

NameHepatocellular carcinoma (A:m6A)
DescriptionYTHDF2 was specifically down-regulated by hypoxia in HCC cells, and that YTHDF2 may function as a tumor suppressor in HCC by negatively modulating the EGFR mRNA stability via its binding the m6A site in the EGFR 3’UTR of mRNA, which in turn impairs the MEK/ERK pathway and consequently impedes the cell proliferation and growth
Related RNA reactionA:m6A
Found in RNAmRNA
Modified TranscriptEGFR
Mapping Technology
Quantification techniques

Enzymes connected to this disease:

Acronym Full name Enzyme Role Organism
YTHDF2 YTH N6-methyladenosine RNA binding protein 2 tumor-suppressor Homo sapiens
 

Publications:

ID Title Authors Journal Details PubMed Id DOI
1043 YTHDF2 suppresses cell proliferation and growth via destabilizing the EGFR mRNA inhepatocellular carcinoma. Zhong L Cancer Lett [details] 30423408 S0304-3835(18)30670-0

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