| Name | Hepatocellular carcinoma (A:m6A) |
| Description | VIRMA is upregulated in HCC. VIRMA induced m6A methylation on the 3′ UTR of GATA3 pre-mRNA, leading to the separation of the RNA-binding protein HuR and the degradation of GATA3 pre-mRNA, leading to altered GATA3 expression and thereby facilitating the malignant phenotypes of hepatoma cells. |
| Related RNA reaction | A:m6A |
| Found in RNA | pre-mRNA |
| Modified Transcript | GATA3 |
| Mapping Technology | MeRIP-seq |
| Quantification techniques |
| Acronym | Full name | Enzyme Role | Organism | Comment |
|---|---|---|---|---|
| VIRMA | vir like m6A methyltransferase associated | oncogene | Homo sapiens |
| ID | Title | Authors | Journal | Details | ||
|---|---|---|---|---|---|---|
| 1046 | KIAA1429 contributes to liver cancer progression through N6-methyladenosine-dependent post-transcriptional modification of GATA3. | Hui Li,Delin Zhang,Lin Xu,Hailing Liu,Xiangyong Hao,Xiaokai Yan,Haotian Liao,Xiangzheng Chen,Kunlin Xie,Jiaxin Li,Mingheng Liao,Jiwei Huang,Kefei Yuan,Yong Zeng, | Mol Cancer | [details] | 31856849 | 10.1186/s12943-019-1106-z |