| Name | Hepatocellular carcinoma (A:m6A) |
| Description | WTAP is significantly up-regulated in HCC and promotes liver cancer development. WTAP-guided m6A modification contributes to the progression of HCC via the HuR-ETS1-p21/p27 axis. ETS proto-oncogene 1 (ETS1) was identified as the downstream effector of WTAP. The m6A modification regulated by WTAP led to post-transcriptional suppression of ETS1, with the implication of Hu-Antigen R (HuR) as an RNA stabilizer. Then ETS1 was found to inhibit the progression of HCC and could rescue the phenotype induced by WTAP deficiency. Moreover, WTAP modulated the G2/M phase of HCC cells through a p21/p27-dependent pattern mediated by ETS1. |
| Related RNA reaction | A:m6A |
| Found in RNA | mRNA |
| Modified Transcript | ETS1 |
| Mapping Technology | |
| Quantification techniques | m6A dot blot assay, MeRIP-qPCR |
| Acronym | Full name | Enzyme Role | Organism | Comment |
|---|---|---|---|---|
| WTAP | Pre-mRNA-splicing regulator WTAP | oncogene | Homo sapiens |
| ID | Title | Authors | Journal | Details | ||
|---|---|---|---|---|---|---|
| 1047 | WTAP facilitates progression of hepatocellular carcinoma via m6A-HuR-dependent epigenetic silencing of ETS1. | Chuanhui Peng,Junru Chen,Diyu Chen,Beng Yang,Bin He,Wendi Hu,Yanpeng Zhang,Hua Liu,Longfei Dai,Haiyang Xie,Lin Zhou,Jian Wu, | Mol Cancer | [details] | 31438961 | 10.1186/s12943-019-1053-8 |