Summary:

NameHepatocellular carcinoma (A:m6A)
DescriptionWTAP is significantly up-regulated in HCC and promotes liver cancer development. WTAP-guided m6A modification contributes to the progression of HCC via the HuR-ETS1-p21/p27 axis. ETS proto-oncogene 1 (ETS1) was identified as the downstream effector of WTAP. The m6A modification regulated by WTAP led to post-transcriptional suppression of ETS1, with the implication of Hu-Antigen R (HuR) as an RNA stabilizer. Then ETS1 was found to inhibit the progression of HCC and could rescue the phenotype induced by WTAP deficiency. Moreover, WTAP modulated the G2/M phase of HCC cells through a p21/p27-dependent pattern mediated by ETS1.
Related RNA reactionA:m6A
Found in RNAmRNA
Modified TranscriptETS1
Mapping Technology
Quantification techniquesm6A dot blot assay, MeRIP-qPCR

Enzymes connected to this disease:

Acronym Full name Enzyme Role Organism
WTAP Pre-mRNA-splicing regulator WTAP oncogene Homo sapiens
 

Publications:

ID Title Authors Journal Details PubMed Id DOI
1047 WTAP facilitates progression of hepatocellular carcinoma via m6A-HuR-dependent epigenetic silencing of ETS1. Yunhao Chen Mol Cancer [details] 31438961 10.1186/s12943-019-1053-8

Copyright © Genesilico - All rights reserved
If you have any advice or suggestions for corrections or improvements, please contact: Andrea Cappannini - lp.vog.bcmii@ininnappaca