| Name | Leukemia (A:m6A) |
| Description | METTL3 is overexpressed in AML; Depletion of METTL3 induces cell differentiation and apoptosis and delays leukemia progression; m6A promotes translation of c-MYC, BCL2, PTEN mRNAs in AML. m6A depletion may activate the PI3K/AKT pathway. |
| Related RNA reaction | A:m6A |
| Found in RNA | mRNA |
| Modified Transcript | c-MYC, BCL2 and PTEN (acute myeloid leukemia) |
| Mapping Technology | miCLIP |
| Quantification techniques | "TLC (thin layer chromatography); MeRIP-qPCR" |
| Acronym | Full name | Enzyme Role | Organism | Comment |
|---|---|---|---|---|
| METTL3 | N6-adenosine-methyltransferase 70 kDa subunit | oncogene | Homo sapiens |
| ID | Title | Authors | Journal | Details | ||
|---|---|---|---|---|---|---|
| 1063 | The N-methyladenosine (mA)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells. | Brian F Pickering,Yuanming Cheng,Sara Zaccara,Diu Nguyen,Gerard Minuesa,Timothy Chou,Arthur Chow,Yogesh Saletore,Matthew MacKay,Jessica Schulman,Christopher Famulare,Minal Patel,Virginia M Klimek,Francine E Garrett-Bakelman,Ari Melnick,Martin Carroll,Christopher E Mason,Samie R Jaffrey, | Nat Med | [details] | 28920958 | 10.1038/nm.4416 |