Leukemia (A:m6A) - disease summary
"METTL3 is overexpressed in AML; Depletion of METTL3 induces cell differentiation and apoptosis and delays leukemia progression; m6A promotes translation of c-MYC, BCL2, PTEN mRNAs in AML. m6A depletion may activate the PI3K/AKT pathway."
Related RNA reaction
Found in RNA
c-MYC, BCL2 and PTEN (acute myeloid leukemia)
"TLC (thin layer chromatography); MeRIP-qPCR"
Enzymes connected to this disease:
N6-adenosine-methyltransferase 70 kDa subunit
The N-methyladenosine (mA)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells.
Ly P Vu
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