Summary:

NameLeukemia (A:m6A)
Description"FTO highly expressed in AML t(11q23)/MLL rearrangements, t(15;17)/PML-RARA, FLT3-ITD and/or NPM1 mutations. FTO enhances leukemic oncogene-mediated cell transformation and leukemogenesis, and inhibits all-trans-retinoic acid (ATRA)-induced AML cell differentiation, through regulating expression of targets such as ASB2 and RARA by reducing m6A levels in these mRNA transcripts."
Related RNA reactionA:m6A
Found in RNAmRNA
Modified TranscriptASB2 and RARA
Mapping TechnologyMeRIP-seq
Quantification techniquesm6A quantification, Gene-Specific m6A qPCR

Enzymes connected to this disease:

Acronym Full name Enzyme Role Organism
FTO Alpha-ketoglutarate-dependent dioxygenase FTO oncogene Homo sapiens
 

Publications:

ID Title Authors Journal Details PubMed Id DOI
1064 FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N(6)-Methyladenosine RNADemethylase. Li Z Cancer Cell [details] 28017614 S1535-6108(16)30560-8

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