| Name | Leukemia (A:m6A) |
| Description | YTHDF2 specifically expands human HSC numbers without skewing lineage fate. Essential role of YTHDF2 in regulating HSC self-renewal BY coupling the posttranscriptional m6A modification to the degradation of mRNAs encoding key transcription factors for self renewal (Tal1) |
| Related RNA reaction | A:m6A |
| Found in RNA | mRNA |
| Modified Transcript | Tal1 |
| Mapping Technology | MeRIP-seq |
| Quantification techniques | m6A quantification |
| Acronym | Full name | Enzyme Role | Organism | Comment |
|---|---|---|---|---|
| YTHDF2 | YTH N6-methyladenosine RNA binding protein 2 | oncogene | Homo sapiens |
| ID | Title | Authors | Journal | Details | ||
|---|---|---|---|---|---|---|
| 1067 | Suppression of mA reader Ythdf2 promotes hematopoietic stem cell expansion. | Pengxu Qian,Wanqing Shao,Hailing Shi,Xi C He,Madelaine Gogol,Zulin Yu,Yongfu Wang,Meijie Qi,Yunfei Zhu,John M Perry,Kai Zhang,Fang Tao,Kun Zhou,Deqing Hu,Yingli Han,Chongbei Zhao,Richard Alexander,Hanzhang Xu,Shiyuan Chen,Allison Peak,Kathyrn Hall,Michael Peterson,Anoja Perera,Jeffrey S Haug,Tari Parmely,Hua Li,Bin Shen,Julia Zeitlinger,Chuan He, | Cell Res | [details] | 30065315 | 10.1038/s41422-018-0072-0 |