Summary:

NameLeukemia (A:m6A)
DescriptionYTHDF2 specifically expands human HSC numbers without skewing lineage fate. Essential role of YTHDF2 in regulating HSC self-renewal BY coupling the posttranscriptional m6A modification to the degradation of mRNAs encoding key transcription factors for self renewal (Tal1)
Related RNA reactionA:m6A
Found in RNAmRNA
Modified TranscriptTal1
Mapping TechnologyMeRIP-seq
Quantification techniquesm6A quantification

Enzymes connected to this disease:

Acronym Full name Enzyme Role Organism
YTHDF2 YTH N6-methyladenosine RNA binding protein 2 oncogene Homo sapiens
 

Publications:

ID Title Authors Journal Details PubMed Id DOI
1067 Suppression of mA reader Ythdf2 promotes hematopoietic stem cell expansion. Zhenrui Li Cell Res [details] 30065315 10.1038/s41422-018-0072-0

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