| Name | Non-small cell lung cancer (A:m6A) |
| Description | Direct physical and functional interaction between METTL3 and the eukaryotic translation initiation factor 3 subunit h (eIF3h). The METTL3–eIF3h interaction is required for enhanced translation (BRD4), formation of densely packed polyribosomes and oncogenic transformation. |
| Related RNA reaction | A:m6A |
| Found in RNA | mRNA |
| Modified Transcript | BRD4 |
| Mapping Technology | MeRIP-seq |
| Quantification techniques |
| Acronym | Full name | Enzyme Role | Organism | Comment |
|---|---|---|---|---|
| METTL3 | N6-adenosine-methyltransferase 70 kDa subunit | oncogene | Homo sapiens |
| ID | Title | Authors | Journal | Details | ||
|---|---|---|---|---|---|---|
| 1088 | mRNA circularization by METTL3-eIF3h enhances translation and promotes oncogenesis. | Shuibin Lin,Wencai Zhang,Qi Liu,Longfei Wang,Julia Ramirez-Moya,Peng Du,Wantae Kim,Shaojun Tang,Piotr Sliz,Pilar Santisteban,Rani E George,William G Richards,Kwok-Kin Wong,Nicolas Locker,Frank J Slack, | Nature | [details] | 30232453 | 10.1038/s41586-018-0538-8 |