Summary:

NameNon-small cell lung cancer (A:m6A)
DescriptionDirect physical and functional interaction between METTL3 and the eukaryotic translation initiation factor 3 subunit h (eIF3h). The METTL3–eIF3h interaction is required for enhanced translation (BRD4), formation of densely packed polyribosomes and oncogenic transformation.
Related RNA reactionA:m6A
Found in RNAmRNA
Modified TranscriptBRD4
Mapping TechnologyMeRIP-seq
Quantification techniques

Enzymes connected to this disease:

Acronym Full name Enzyme Role Organism
METTL3 N6-adenosine-methyltransferase 70 kDa subunit oncogene Homo sapiens
 

Publications:

ID Title Authors Journal Details PubMed Id DOI
1088 mRNA circularization by METTL3-eIF3h enhances translation and promotes oncogenesis. Junho Choe Nature [details] 30232453 10.1038/s41586-018-0538-8

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