| Name | Non-small cell lung cancer (A:m6A) |
| Description | METTL3 is overexpressed in lung cancer tissues and cell lines. The m6A mRNA methylation initiated by METTL3 promotes YAP mRNA translation via recruiting YTHDF1/3 and eIF3b to the translation initiation complex and increases YAP mRNA stability through regulating the MALAT1-miR-1914-3p- YAP axis. The increased YAP expression and activity induce NSCLC drug resistance and metastasis. |
| Related RNA reaction | A:m6A |
| Found in RNA | mRNA, lncRNA |
| Modified Transcript | YAP, MALAT1 |
| Mapping Technology | |
| Quantification techniques | HPLC–tandem mass spectrometry, MeRIP-PCR |
| Acronym | Full name | Enzyme Role | Organism | Comment |
|---|---|---|---|---|
| METTL3 | N6-adenosine-methyltransferase 70 kDa subunit | oncogene | Homo sapiens |
| ID | Title | Authors | Journal | Details | ||
|---|---|---|---|---|---|---|
| 1089 | mA mRNA methylation initiated by METTL3 directly promotes YAP translation and increases YAP activity by regulating the MALAT1-miR-1914-3p-YAP axis to induce NSCLC drug resistance and metastasis. | Jiwei Guo,Yan Wu,Jing Du,Lijuan Yang,Xiaohong Wang,Weihua Di,Baoguang Hu,Jiajia An,Lingqun Kong,Lei Pan, | J Hematol Oncol | [details] | 31818312 | 10.1186/s13045-019-0830-6 |