| Name | Non-small cell lung cancer (A:m6A) |
| Description | METTL3 is overexpressed in lung cancer tissues and cell lines. The m6A mRNA methylation initiated by METTL3 promotes YAP mRNA translation via recruiting YTHDF1/3 and eIF3b to the translation initiation complex and increases YAP mRNA stability through regulating the MALAT1-miR-1914-3p- YAP axis. The increased YAP expression and activity induce NSCLC drug resistance and metastasis. |
| Related RNA reaction | A:m6A |
| Found in RNA | mRNA, lncRNA |
| Modified Transcript | YAP, MALAT1 |
| Mapping Technology | |
| Quantification techniques | HPLC–tandem mass spectrometry, MeRIP-PCR |