Summary:

NameNon-small cell lung cancer (A:m6A)
DescriptionIncreased m6A methylation level reduces USP7 mRNA expression and reduces both the proliferation rate of lung cancer cells and the capacity of colony formation. The increased USP7 mRNA stability through FTO mediated demethylation explaines FTO oncogenic role for the growth of NSCLC cells
Related RNA reactionA:m6A
Found in RNAmRNA
Modified TranscriptUSP7
Mapping Technology
Quantification techniquesMeRIP-qPCR

Enzymes connected to this disease:

Acronym Full name Enzyme Role Organism
FTO Alpha-ketoglutarate-dependent dioxygenase FTO oncogene Homo sapiens
 

Publications:

ID Title Authors Journal Details PubMed Id DOI
1091 The m6A demethylase FTO promotes the growth of lung cancer cells by regulating them6A level of USP7 mRNA. Li J Biochem Biophys Res Commun [details] 30905413 S0006-291X(19)30482-6

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