| Name | Non-small cell lung cancer (A:m6A) |
| Description | Increased m6A methylation level reduces MZF1 mRNA expression. FTO upregulation mediates MZF1 mRNA demethylation and increased MZF1 mRNA stability. This leads to an enhanced MZF1 expression, which explains the oncogenic roles of FTO in LUSCs |
| Related RNA reaction | A:m6A |
| Found in RNA | mRNA |
| Modified Transcript | MZF1 |
| Mapping Technology | |
| Quantification techniques | m6A quantification |
| Acronym | Full name | Enzyme Role | Organism | Comment |
|---|---|---|---|---|
| FTO | Alpha-ketoglutarate-dependent dioxygenase FTO | oncogene | Homo sapiens |
| ID | Title | Authors | Journal | Details | ||
|---|---|---|---|---|---|---|
| 1092 | m(6)A demethylase FTO facilitates tumor progression in lung squamous cell carcinomaby regulating MZF1 expression. | Liu J | Biochem Biophys Res Commun | [details] | 29842885 | S0006-291X(18)31252-X |