Summary:

NameNon-small cell lung cancer (A:m6A)
DescriptionIncreased m6A methylation level reduces MZF1 mRNA expression. FTO upregulation mediates MZF1 mRNA demethylation and increased MZF1 mRNA stability. This leads to an enhanced MZF1 expression, which explains the oncogenic roles of FTO in LUSCs
Related RNA reactionA:m6A
Found in RNAmRNA
Modified TranscriptMZF1
Mapping Technology
Quantification techniquesm6A quantification

Enzymes connected to this disease:

Acronym Full name Enzyme Role Organism
FTO Alpha-ketoglutarate-dependent dioxygenase FTO oncogene Homo sapiens
 

Publications:

ID Title Authors Journal Details PubMed Id DOI
1092 m(6)A demethylase FTO facilitates tumor progression in lung squamous cell carcinomaby regulating MZF1 expression. Liu J Biochem Biophys Res Commun [details] 29842885 S0006-291X(18)31252-X

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