Summary:

NameNon-small cell lung cancer (A:m6A)
DescriptionYTHDF2 is upregulated in lung cancer tissues and it recognizes m6A sites on the 3′UTR of 6-phosphogluconate dehydrogenase(6PGD) and facilitates its translation, which advances the pentose phosphate pathway (PPP) flux , which is crucial for tumor growth.
Related RNA reactionA:m6A
Found in RNAmRNA
Modified Transcript6PGD
Mapping TechnologyMeRIP-seq
Quantification techniquesMeRIP RT-PCR

Enzymes connected to this disease:

Acronym Full name Enzyme Role Organism
YTHDF2 YTH N6-methyladenosine RNA binding protein 2 oncogene Homo sapiens
 

Publications:

ID Title Authors Journal Details PubMed Id DOI
1093 YTH domain family 2 promotes lung cancer cell growth by facilitating6-phosphogluconate dehydrogenase mRNA translation. Sheng H Carcinogenesis [details] 31504235 5561531

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