| Name | Non-small cell lung cancer (A:m6A) |
| Description | YTHDF2 is upregulated in lung cancer tissues and it recognizes m6A sites on the 3′UTR of 6-phosphogluconate dehydrogenase(6PGD) and facilitates its translation, which advances the pentose phosphate pathway (PPP) flux , which is crucial for tumor growth. |
| Related RNA reaction | A:m6A |
| Found in RNA | mRNA |
| Modified Transcript | 6PGD |
| Mapping Technology | MeRIP-seq |
| Quantification techniques | MeRIP RT-PCR |
| Acronym | Full name | Enzyme Role | Organism |
|---|---|---|---|
| YTHDF2 | YTH N6-methyladenosine RNA binding protein 2 | oncogene | Homo sapiens |
| ID | Title | Authors | Journal | Details | ||
|---|---|---|---|---|---|---|
| 1093 | YTH domain family 2 promotes lung cancer cell growth by facilitating6-phosphogluconate dehydrogenase mRNA translation. | Sheng H | Carcinogenesis | [details] | 31504235 | 5561531 |