| Name | Pancreatic cancer (A:m6A) |
| Description | YTHDF2 binds to m6A-containing mRNAs and regulates their localization and stability. YTHDF2 upregulation increases the proliferative abilities of pancreatic cells by enhancing Akt/GSK3b/CyclinD1 pathway and on the opposite side it represses the invasion and migration abilities (EMT) by supressing the YAP pathway |
| Related RNA reaction | A:m6A |
| Found in RNA | mRNA |
| Modified Transcript | p-AKT/GSK3b/CyclinD1 |
| Mapping Technology | |
| Quantification techniques |
| Acronym | Full name | Enzyme Role | Organism | Comment |
|---|---|---|---|---|
| YTHDF2 | YTH N6-methyladenosine RNA binding protein 2 | oncogene | Homo sapiens |
| ID | Title | Authors | Journal | Details | ||
|---|---|---|---|---|---|---|
| 1104 | YTH domain family 2 orchestrates epithelial-mesenchymal transition/proliferation dichotomy in pancreatic cancer cells. | Yaocheng Sun,Xiao Xu,Dawei Wang,Junbo He,Hailang Zhou,Ying Lu,Jian Zeng,Fengyi Du,Aihua Gong, | Cell Cycle | [details] | 29135329 | 10.1080/15384101.2017.1380125 |