Modomics - A Database of RNA Modifications


NamePancreatic cancer (A:m6A)
DescriptionYTHDF2 binds to m6A-containing mRNAs and regulates their localization and stability. YTHDF2 upregulation increases the proliferative abilities of pancreatic cells by enhancing Akt/GSK3b/CyclinD1 pathway and on the opposite side it represses the invasion and migration abilities (EMT) by supressing the YAP pathway
Related RNA reactionA:m6A
Found in RNAmRNA
Modified TranscriptYAP
Mapping Technology
Quantification techniques

Enzymes connected to this disease:

Acronym Full name Enzyme Role Organism
YTHDF2 YTH N6-methyladenosine RNA binding protein 2 tumor-suppressor Homo sapiens


ID Title Authors Journal Details PubMed Id DOI
1104 YTH domain family 2 orchestrates epithelial-mesenchymal transition/proliferation dichotomy in pancreatic cancer cells. Jixiang Chen Cell Cycle [details] 29135329 10.1080/15384101.2017.1380125

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