Summary:

NameRenal cell carcinoma (A:m6A)
DescriptionDemethylation of adenosine residues in the 3′‐UTR of PGC‐1α mRNA (induced by FTO), leads to increased PGC‐1α mRNA stability and protein expression, and increased mitochondrial biogenesis, oxidative stress and tumour suppression
Related RNA reactionA:m6A
Found in RNAmRNA
Modified TranscriptPGC‐1α
Mapping Technology
Quantification techniquesMeRIP-qPCR

Enzymes connected to this disease:

Acronym Full name Enzyme Role Organism
FTO Alpha-ketoglutarate-dependent dioxygenase FTO tumor-suppressor Homo sapiens
 

Publications:

ID Title Authors Journal Details PubMed Id DOI
1116 N6-methyladenosine demethylase FTO suppresses clear cell renal cell carcinoma through a novel FTO-PGC-1α signalling axis. Changshui Zhuang J Cell Mol Med [details] 30648791 10.1111/jcmm.14128

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