| Name | Renal cell carcinoma (A:m6A) |
| Description | Demethylation of adenosine residues in the 3′‐UTR of PGC‐1α mRNA (induced by FTO), leads to increased PGC‐1α mRNA stability and protein expression, and increased mitochondrial biogenesis, oxidative stress and tumour suppression |
| Related RNA reaction | A:m6A |
| Found in RNA | mRNA |
| Modified Transcript | PGC‐1α |
| Mapping Technology | |
| Quantification techniques | MeRIP-qPCR |
| Acronym | Full name | Enzyme Role | Organism |
|---|---|---|---|
| FTO | Alpha-ketoglutarate-dependent dioxygenase FTO | tumor-suppressor | Homo sapiens |
| ID | Title | Authors | Journal | Details | ||
|---|---|---|---|---|---|---|
| 1116 | N6-methyladenosine demethylase FTO suppresses clear cell renal cell carcinoma through a novel FTO-PGC-1α signalling axis. | Changshui Zhuang | J Cell Mol Med | [details] | 30648791 | 10.1111/jcmm.14128 |