Summary:

NameRenal cell carcinoma (A:m6A)
DescriptionIn RCC cell lines and tissues, WTAP is significantly overexpressed. Mechanistic studies exhibited that CDK2 expression is positively associated with the expression of WTAP. Moreover, WTAP stabilizes CDK2 transcript to enhance CDK2 expression via binding to 3′-UTR of CDK2 transcript.
Related RNA reactionA:m6A
Found in RNAmRNA
Modified TranscriptCDK2
Mapping Technology
Quantification techniques

Enzymes connected to this disease:

Acronym Full name Enzyme Role Organism
WTAP Pre-mRNA-splicing regulator WTAP oncogene Homo sapiens
 

Publications:

ID Title Authors Journal Details PubMed Id DOI
1117 Wilms' tumor 1-associating protein promotes renal cell carcinoma proliferation by regulating CDK2 mRNA stability. Jingyuan Tang J Exp Clin Cancer Res [details] 29482572 10.1186/s13046-018-0706-6

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