Summary

Full namewyosine
IUPAC name3-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4,6-dimethylimidazo[1,2-a]purin-9-one
Short nameimG
MODOMICS code34G
Synonyms
3-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4,6-dimethylimidazo[1,2-a]purin-9-one
3-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4,6-dimethyl-3H-imidazo[1,2-a]purin-9(4H)-one
3-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-4,6-dimethyl-imidazo[1,2-a]purin-9-one
{3H-Diimidazo[1,2-a:4',5'-d]pyrimidin-9-one,} 4,9- dihydro-4, 6-dimethyl-3-B-D-ribofuranosyl-
3-Ribofuranosyl-4,9-dihydro-4,6-dimethyl-9-oxo-1H-imidazo(1,2-a)purine
52662-10-9
9H-Imidazo(1,2-a)purin-9-one, 3,4-dihydro-4,6-dimethyl-3-beta-D-ribofuranosyl-
AC1L570Q
CID171185
DTXSID70200631
IMG
NSC628338
Q2595726
wyosin
Wyosine
Y Base 3-beta-D-ribofuranoside
Y Nucleoside
Yt
Yt Nucleoside

Nature of the modified residueNatural
RNAMods code
Residue unique ID139
Found in RNAYes
Related nucleotides426

Chemical information

Sum formulaC14H17N5O5
Type of moietynucleoside
Degeneracynot applicable
SMILESC[n]1c2c(nc[n]2[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)[n]2cc(C)nc12
logP-1.6974
TPSA127.04
Number of atoms24
Number of Hydrogen Bond Acceptors 1 (HBA1)7
Number of Hydrogen Bond Acceptors 2 (HBA2)10
Number of Hydrogen Bond Donors (HBD)3
PDB no exac match , link to the most similar ligand NOS
HMDB (Human Metabolome Database) no exac match, link to the most similar ligand HMDB0003950
InChIInChI=1S/C14H17N5O5/c1-6-3-18-12(23)8-11(17(2)14(18)16-6)19(5-15-8)13-10(22)9(21)7(4-20)24-13/h3,5,7,9-10,13,20-22H,4H2,1-2H3/t7-,9-,10-,13-/m1/s1
InChIKeyJCZSFCLRSONYLH-QYVSTXNMSA-N
Search the molecule in external databases ChEMBL  ChemAgora  ChEBI  PubChem Compound Database  Ligand Expo  ChemSpider  WIPO 
PubChem CID
PubChem SIDs

* Chemical properties calculated with Open Babel - O'Boyle et al. Open Babel: An open chemical toolbox. J Cheminform 3, 33 (2011) (link)


Download Structures

2D   .png .mol .mol2 .sdf .pdb .smi
3D   .mol .mol2 .sdf .pdb


Predicted CYP Metabolic Sites

CYP3A4 CYP2D6 CYP2C9
imG imG imG

* CYP Metabolic sites predicted with SMARTCyp. SMARTCyp is a method for prediction of which sites in a molecule that are most liable to metabolism by Cytochrome P450. It has been shown to be applicable to metabolism by the isoforms 1A2, 2A6, 2B6, 2C8, 2C19, 2E1, and 3A4 (CYP3A4), and specific models for the isoform 2C9 (CYP2C9) and isoform 2D6 (CYP2D6). CYP3A4, CYP2D6, and CYP2C9 are the three of the most important enzymes in drug metabolism since they are involved in the metabolism of more than half of the drugs used today. The three top-ranked atoms are highlighted. See: SmartCYP and SmartCYP - background; Patrik Rydberg, David E. Gloriam, Lars Olsen, The SMARTCyp cytochrome P450 metabolism prediction server, Bioinformatics, Volume 26, Issue 23, 1 December 2010, Pages 2988–2989 (link)


LC-MS Information

Monoisotopic mass335.123
Average mass335.315
[M+H]+336.1308
Product ions204
Normalized LC elution time * not available
LC elution order/characteristics not available

* normalized to guanosine (G), measured with a RP C-18 column with acetonitrile/ammonium acetate as mobile phase.

Reactions producing wyosine

Name
imG-14:imG

Publications

Title Authors Journal Details PubMed Id DOI
Structure of wye (Yt base) and wyosine (Yt) from Torulopsis utilis phenylalanine transfer ribonucleic acid. Kasai H, Goto M, Ikeda K, Zama M, Mizuno Y, Takemura S, Matsuura S, Sugimoto T, Goto T Biochemistry [details] 942858 -

Last modification of this entry: Sept. 29, 2021


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