Summary

Full name5-(carboxyhydroxymethyl)uridine methyl ester
IUPAC namemethyl 2-[1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2,4-dioxopyrimidin-5-yl]-2-hydroxyacetate
Short namemchm5U
MODOMICS code522U
Synonyms
4-Hydroxy-5-(1-hydroxy-2-methoxy-2-oxoethyl)-1-pentofuranosylpyrimidin-2(1H)-one
5-(Carboxy uridinemethylester
5-(carboxyhydroxymethyl)uridine methyl ester
5-(Carboxy(hydroxy)methyl)uridine methyl ester
89665-83-8
945684-13-9
AC1L3SH5
Chmu-methyl ester
CID146066
DTXSID201008938
methyl 2-[1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2,4-dioxopyrimidin-5-yl]-2-hydroxyacetate
Methyl 2-(1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2-hydroxyacetate
SCHEMBL159808

Nature of the modified residueNatural
RNAMods code,
Residue unique ID85
Found in RNAYes
Related nucleotides351
Enzymes ALKBH8 (Homo sapiens)
Found in phylogenyEukaryota
Found naturally in RNA typestRNA

Chemical information

Sum formulaC12H16N2O9
Type of moietynucleoside
Degeneracynot applicable
SMILESCOC(C(c1c(=O)[nH]c(=O)[n]([C@H]2[C@H](O)[C@H](O)[C@@H](CO)O2)c1)O)=O
logP-3.6455
TPSA171.31
Number of atoms23
Number of Hydrogen Bond Acceptors 1 (HBA1)9
Number of Hydrogen Bond Acceptors 2 (HBA2)10
Number of Hydrogen Bond Donors (HBD)5
PDB no exac match , link to the most similar ligand 38T
HMDB (Human Metabolome Database) no exac match, link to the most similar ligand HMDB0000884
InChIInChI=1S/C12H16N2O9/c1-22-11(20)6(16)4-2-14(12(21)13-9(4)19)10-8(18)7(17)5(3-15)23-10/h2,5-8,10,15-18H,3H2,1H3,(H,13,19,21)/t5-,6?,7-,8-,10-/m1/s1
InChIKeyJNVLKTZUCGRYNN-LQGIRWEJSA-N
Search the molecule in external databases ChEMBL  ChemAgora  ChEBI  PubChem Compound Database  Ligand Expo  ChemSpider  WIPO 
PubChem CID
PubChem SIDs

* Chemical properties calculated with Open Babel - O'Boyle et al. Open Babel: An open chemical toolbox. J Cheminform 3, 33 (2011) (link)


Download Structures

2D   .png .mol .mol2 .sdf .pdb .smi
3D   .mol .mol2 .sdf .pdb

Tautomers

Tautomers SMILES
COC(C(C1C(=O)NC(=O)N(C2C(O)C(O)C(CO)O2)C1)=O)=O tautomer #0
COC(C(c1c(=O)[nH]c(=O)n(C2C(O)C(O)C(CO)O2)c1)=O)O tautomer #1
COC(C(c1c(=O)[nH]c(=O)n(C2C(O)C(O)C(CO)O2)c1)O)=O tautomer #2
COC(C(=C1C(=O)NC(=O)N(C2C(O)C(O)C(CO)O2)C1)O)=O tautomer #3
COC(C(C1=C(O)NC(=O)N(C2C(O)C(O)C(CO)O2)C1)=O)=O tautomer #4
COC(=C(c1c(=O)[nH]c(=O)n(C2C(O)C(O)C(CO)O2)c1)O)O tautomer #5
COC(C(c1c(O)nc(=O)n(C2C(O)C(O)C(CO)O2)c1)=O)O tautomer #6
COC(C(C1C(=O)N=C(O)N(C2C(O)C(O)C(CO)O2)C1)=O)=O tautomer #7
COC(C(C1C(O)=NC(=O)N(C2C(O)C(O)C(CO)O2)C1)=O)=O tautomer #8
COC(C(c1c(O)nc(=O)n(C2C(O)C(O)C(CO)O2)c1)O)=O tautomer #9
COC(C(c1c(=O)nc(O)n(C2C(O)C(O)C(CO)O2)c1)=O)O tautomer #10
COC(C(c1c(=O)nc(O)n(C2C(O)C(O)C(CO)O2)c1)O)=O tautomer #11
COC(C(=C1C(O)=NC(=O)N(C2C(O)C(O)C(CO)O2)C1)O)=O tautomer #12
COC(C(=C1C(=O)N=C(O)N(C2C(O)C(O)C(CO)O2)C1)O)=O tautomer #13
COC(C(C1=C(O)N=C(O)N(C2C(O)C(O)C(CO)O2)C1)=O)=O tautomer #14
COC(=C(c1c(O)nc(=O)n(C2C(O)C(O)C(CO)O2)c1)O)O tautomer #15
COC(=C(c1c(=O)nc(O)n(C2C(O)C(O)C(CO)O2)c1)O)O tautomer #16

Tautomer image Show Image

Predicted CYP Metabolic Sites

CYP3A4 CYP2D6 CYP2C9
mchm5U mchm5U mchm5U

* CYP Metabolic sites predicted with SMARTCyp. SMARTCyp is a method for prediction of which sites in a molecule that are most liable to metabolism by Cytochrome P450. It has been shown to be applicable to metabolism by the isoforms 1A2, 2A6, 2B6, 2C8, 2C19, 2E1, and 3A4 (CYP3A4), and specific models for the isoform 2C9 (CYP2C9) and isoform 2D6 (CYP2D6). CYP3A4, CYP2D6, and CYP2C9 are the three of the most important enzymes in drug metabolism since they are involved in the metabolism of more than half of the drugs used today. The three top-ranked atoms are highlighted. See: SmartCYP and SmartCYP - background; Patrik Rydberg, David E. Gloriam, Lars Olsen, The SMARTCyp cytochrome P450 metabolism prediction server, Bioinformatics, Volume 26, Issue 23, 1 December 2010, Pages 2988–2989 (link)


LC-MS Information

Monoisotopic mass332.0856
Average mass332.263
[M+H]+333.0934
Product ions129/183/316/201/297
Normalized LC elution time * not available
LC elution order/characteristics not available

* normalized to guanosine (G), measured with a RP C-18 column with acetonitrile/ammonium acetate as mobile phase.

Chemical groups contained

TypeSubtype
othercarboxymethyl
otherhydroxyl
othermethylester

Reactions producing 5-(carboxyhydroxymethyl)uridine methyl ester

Name
mcm5U:mchm5U
chm5U:mchm5U

Reactions starting from 5-(carboxyhydroxymethyl)uridine methyl ester

Name
mchm5U:mchm5Um

Last modification of this entry: Sept. 29, 2021


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