Summary

Full namegalactosyl-queuosine
Short namegalQ
MODOMICS code104G
Nature of the modified residueNatural
RNAMods code9
Residue unique ID86
Found in RNAYes
Related nucleotides415
Enzymes Man/Gal-Q-transferase (various eukaryotes)
Found in phylogenyEukaryota
Found naturally in RNA typestRNA

Chemical information

Sum formulaC23H33N5O12
Type of moietynucleoside
Degeneracynot applicable
SMILESNc1[nH]c(=O)c2c([n]([C@H]3[C@H](O)[C@H](O)[C@@H](CO)O3)cc2CN[C@@H]2[C@@H](O[C@H]3C(O)[C@H](O)[C@@H](O)C(CO)O3)[C@@H](O)C=C2)n1
logP-4.5356
TPSA278.26
Number of atoms40
Number of Hydrogen Bond Acceptors 1 (HBA1)15
Number of Hydrogen Bond Acceptors 2 (HBA2)16
Number of Hydrogen Bond Donors (HBD)11
PDB no exac match , link to the most similar ligand 56B
HMDB (Human Metabolome Database) no exac match, link to the most similar ligand HMDB0011596
InChIInChI=1S/C23H33N5O12/c24-23-26-19-12(20(37)27-23)7(4-28(19)21-16(35)14(33)10(5-29)38-21)3-25-8-1-2-9(31)18(8)40-22-17(36)15(34)13(32)11(6-30)39-22/h1-2,4,8-11,13-18,21-22,25,29-36H,3,5-6H2,(H3,24,26,27,37)/t8-,9-,10+,11?,13-,14+,15+,16+,17?,18+,21+,22-/m0/s1
InChIKeyPMEPLRGWRNWIRD-HNJWXGMFSA-N
Search the molecule in external databases ChEMBL  ChemAgora  ChEBI  PubChem Compound Database  Ligand Expo  ChemSpider  WIPO 

* Chemical properties calculated with Open Babel - O'Boyle et al. Open Babel: An open chemical toolbox. J Cheminform 3, 33 (2011) (link)


Download Structures

2D   .png .mol .mol2 .sdf .pdb .smi
3D   .mol .mol2 .sdf .pdb

Tautomers

Tautomers SMILES
N=C1NC(O)c2c(n(C3C(O)C(O)C(CO)O3)cc2C=NC4C(OC5C(O)C(O)C(O)C(CO)O5)C(O)C=C4)N1 tautomer #0
N=c1[nH]c(=O)c2c(n(C3C(O)C(O)C(CO)O3)cc2CNC4C(OC5C(O)C(O)C(O)C(CO)O5)C(O)C=C4)[nH]1 tautomer #1
Nc1nc(O)c2c(n(C3C(O)C(O)C(CO)O3)cc2CNC4C(OC5C(O)C(O)C(O)C(CO)O5)C(O)C=C4)n1 tautomer #2
NC1=NC(O)c2c(n(C3C(O)C(O)C(CO)O3)cc2C=NC4C(OC5C(O)C(O)C(O)C(CO)O5)C(O)C=C4)N1 tautomer #3
Nc1nc(=O)c2c(n(C3C(O)C(O)C(CO)O3)cc2CNC4C(OC5C(O)C(O)C(O)C(CO)O5)C(O)C=C4)[nH]1 tautomer #4
Nc1[nH]c(=O)c2c(n(C3C(O)C(O)C(CO)O3)cc2CNC4C(OC5C(O)C(O)C(O)C(CO)O5)C(O)C=C4)n1 tautomer #5
N=c1[nH]c(O)c2c(n(C3C(O)C(O)C(CO)O3)cc2CNC4C(OC5C(O)C(O)C(O)C(CO)O5)C(O)C=C4)n1 tautomer #6
Nc1nc(O)c2c(N(C3C(O)C(O)C(CO)O3)CC2C=NC4C(OC5C(O)C(O)C(O)C(CO)O5)C(O)C=C4)n1 tautomer #7
Nc1nc(O)c2c(N(C3C(O)C(O)C(CO)O3)CC2=CNC4C(OC5C(O)C(O)C(O)C(CO)O5)C(O)C=C4)n1 tautomer #8
N=C1NC(=O)C2C(N(C3C(O)C(O)C(CO)O3)C=C2C=NC4C(OC5C(O)C(O)C(O)C(CO)O5)C(O)C=C4)N1 tautomer #9
N=C1NC(=O)C=2C(N(C3C(O)C(O)C(CO)O3)CC2C=NC4C(OC5C(O)C(O)C(O)C(CO)O5)C(O)C=C4)N1 tautomer #10
N=C1NC(=O)C2C(N(C3C(O)C(O)C(CO)O3)C=C2CNC4C(OC5C(O)C(O)C(O)C(CO)O5)C(O)C=C4)=N1 tautomer #11
N=C1NC(=O)C2C(N(C3C(O)C(O)C(CO)O3)CC2C=NC4C(OC5C(O)C(O)C(O)C(CO)O5)C(O)C=C4)=N1 tautomer #12
N=C1NC(O)C=2C(N(C3C(O)C(O)C(CO)O3)CC2C=NC4C(OC5C(O)C(O)C(O)C(CO)O5)C(O)C=C4)=N1 tautomer #13
N=C1NC(=O)C=2C(N(C3C(O)C(O)C(CO)O3)CC2CNC4C(OC5C(O)C(O)C(O)C(CO)O5)C(O)C=C4)=N1 tautomer #14
N=c1[nH]c(=O)c2c(N(C3C(O)C(O)C(CO)O3)CC2C=NC4C(OC5C(O)C(O)C(O)C(CO)O5)C(O)C=C4)[nH]1 tautomer #15
N=C1NC(=O)C2C(N(C3C(O)C(O)C(CO)O3)CC2=CNC4C(OC5C(O)C(O)C(O)C(CO)O5)C(O)C=C4)=N1 tautomer #16
N=c1[nH]c(=O)c2c(N(C3C(O)C(O)C(CO)O3)CC2=CNC4C(OC5C(O)C(O)C(O)C(CO)O5)C(O)C=C4)[nH]1 tautomer #17
Nc1nc(O)c2c(n(C3C(O)C(O)C(CO)O3)cc2CNC4C(OC5C(O)C(O)C(O)C(CO)O5)C(O)C=C4)n1 tautomer #18
NC1=NC(=O)C2C(N(C3C(O)C(O)C(CO)O3)C=C2C=NC4C(OC5C(O)C(O)C(O)C(CO)O5)C(O)C=C4)N1 tautomer #19
NC1=NC(=O)C=2C(N(C3C(O)C(O)C(CO)O3)CC2C=NC4C(OC5C(O)C(O)C(O)C(CO)O5)C(O)C=C4)N1 tautomer #20
NC1=NC(=O)C2C(N(C3C(O)C(O)C(CO)O3)C=C2CNC4C(OC5C(O)C(O)C(O)C(CO)O5)C(O)C=C4)=N1 tautomer #21
NC1=NC(=O)C2C(N(C3C(O)C(O)C(CO)O3)CC2C=NC4C(OC5C(O)C(O)C(O)C(CO)O5)C(O)C=C4)=N1 tautomer #22
NC1=NC(O)C=2C(N(C3C(O)C(O)C(CO)O3)CC2C=NC4C(OC5C(O)C(O)C(O)C(CO)O5)C(O)C=C4)=N1 tautomer #23
NC1=NC(=O)C=2C(N(C3C(O)C(O)C(CO)O3)CC2CNC4C(OC5C(O)C(O)C(O)C(CO)O5)C(O)C=C4)=N1 tautomer #24
Nc1nc(=O)c2c(N(C3C(O)C(O)C(CO)O3)CC2C=NC4C(OC5C(O)C(O)C(O)C(CO)O5)C(O)C=C4)[nH]1 tautomer #25
NC1=NC(=O)C2C(N(C3C(O)C(O)C(CO)O3)CC2=CNC4C(OC5C(O)C(O)C(O)C(CO)O5)C(O)C=C4)=N1 tautomer #26
N=c1nc(O)c2c(n(C3C(O)C(O)C(CO)O3)cc2CNC4C(OC5C(O)C(O)C(O)C(CO)O5)C(O)C=C4)[nH]1 tautomer #27
Nc1nc(=O)c2c(N(C3C(O)C(O)C(CO)O3)CC2=CNC4C(OC5C(O)C(O)C(O)C(CO)O5)C(O)C=C4)[nH]1 tautomer #28
N=C1NC(O)=C2C(N(C3C(O)C(O)C(CO)O3)C=C2C=NC4C(OC5C(O)C(O)C(O)C(CO)O5)C(O)C=C4)N1 tautomer #29
N=c1[nH]c(O)c2c(N(C3C(O)C(O)C(CO)O3)CC2C=NC4C(OC5C(O)C(O)C(O)C(CO)O5)C(O)C=C4)n1 tautomer #30
N=c1[nH]c(O)c2c(N(C3C(O)C(O)C(CO)O3)CC2=CNC4C(OC5C(O)C(O)C(O)C(CO)O5)C(O)C=C4)n1 tautomer #31
NC1=NC(O)=C2C(N(C3C(O)C(O)C(CO)O3)C=C2C=NC4C(OC5C(O)C(O)C(O)C(CO)O5)C(O)C=C4)N1 tautomer #32
N=C1N=C(O)C2C(N(C3C(O)C(O)C(CO)O3)C=C2C=NC4C(OC5C(O)C(O)C(O)C(CO)O5)C(O)C=C4)N1 tautomer #33
N=C1N=C(O)C=2C(N(C3C(O)C(O)C(CO)O3)CC2C=NC4C(OC5C(O)C(O)C(O)C(CO)O5)C(O)C=C4)N1 tautomer #34
N=C1N=C(O)C2C(N(C3C(O)C(O)C(CO)O3)C=C2CNC4C(OC5C(O)C(O)C(O)C(CO)O5)C(O)C=C4)=N1 tautomer #35
N=C1N=C(O)C2C(N(C3C(O)C(O)C(CO)O3)CC2C=NC4C(OC5C(O)C(O)C(O)C(CO)O5)C(O)C=C4)=N1 tautomer #36
N=C1N=C(O)C=2C(N(C3C(O)C(O)C(CO)O3)CC2CNC4C(OC5C(O)C(O)C(O)C(CO)O5)C(O)C=C4)=N1 tautomer #37
N=c1nc(O)c2c(N(C3C(O)C(O)C(CO)O3)CC2C=NC4C(OC5C(O)C(O)C(O)C(CO)O5)C(O)C=C4)[nH]1 tautomer #38
N=C1N=C(O)C2C(N(C3C(O)C(O)C(CO)O3)CC2=CNC4C(OC5C(O)C(O)C(O)C(CO)O5)C(O)C=C4)=N1 tautomer #39
N=c1nc(O)c2c(N(C3C(O)C(O)C(CO)O3)CC2=CNC4C(OC5C(O)C(O)C(O)C(CO)O5)C(O)C=C4)[nH]1 tautomer #40

Tautomer image Show Image

Predicted CYP Metabolic Sites

CYP3A4 CYP2D6 CYP2C9
galQ galQ galQ

* CYP Metabolic sites predicted with SMARTCyp. SMARTCyp is a method for prediction of which sites in a molecule that are most liable to metabolism by Cytochrome P450. It has been shown to be applicable to metabolism by the isoforms 1A2, 2A6, 2B6, 2C8, 2C19, 2E1, and 3A4 (CYP3A4), and specific models for the isoform 2C9 (CYP2C9) and isoform 2D6 (CYP2D6). CYP3A4, CYP2D6, and CYP2C9 are the three of the most important enzymes in drug metabolism since they are involved in the metabolism of more than half of the drugs used today. The three top-ranked atoms are highlighted. See: SmartCYP and SmartCYP - background; Patrik Rydberg, David E. Gloriam, Lars Olsen, The SMARTCyp cytochrome P450 metabolism prediction server, Bioinformatics, Volume 26, Issue 23, 1 December 2010, Pages 2988–2989 (link)


LC-MS Information

Monoisotopic mass571.2126
Average mass571.534
[M+H]+572.2204
Product ions440
Normalized LC elution time * not available
LC elution order/characteristics not available

* normalized to guanosine (G), measured with a RP C-18 column with acetonitrile/ammonium acetate as mobile phase.

Chemical groups contained

TypeSubtype
glycosyl groupgalactosyl

Reactions producing galactosyl-queuosine

Name
Q:galQ

Publications

Title Authors Journal Details PubMed Id DOI
Letter: The structure of Q* nucleoside isolated from rabbit liver transfer ribonucleic acid. Kasai H, Nakanishi K, Macfarlane RD, Torgerson DF, Ohashi Z, McCloskey JA, Gross HJ, Nishimura S J Am Chem Soc [details] 950430 -

Last modification of this entry: Sept. 29, 2021


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