Sua5 from Saccharomyces cerevisiae - protein summary.
tRNA threonylcarbamoyladenosine biosynthesis protein SUA5
Position of modification - modification:
t:37 - t6A
Sua5 homologues are found in genomes of organisms from all three domains of life. This protein binds threonine, ATP and U36A37-containing tRNA. Together with several other proteins of the so-called EKC/KEOPS complex, ATP, threonine and bicarbonate as cofactors, they catalyze the in vivo formation of t6A (threonyl-carbamoylation) at position 37 of all eukaryotic tRNAs decoding ANN codons (Ile, Met, Thr, Lys, Asn, Arg and Ser). However the detailed stepwise mechanism of t6A formation is still not known (March 2012).
Isolation and characterization of SUA5, a novel gene required for normal growth in Saccharomyces cerevisiae.
Na JG, Pinto I, Hampsey M
The universal YrdC/Sua5 family is required for the formation of threonylcarbamoyladenosine in tRNA.
El Yacoubi B, Lyons B, Cruz Y, Reddy R, Nordin B, Agnelli F, Williamson JR, Schimmel P, Swairjo MA, de Crecy-Lagard V
Nucleic Acids Res
The Sua5 protein is essential for normal translational regulation in yeast.
Lin CA, Ellis SR, True HL
Mol Cell Biol
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