| Full name: |
rRNA adenine N-6-methyltransferase |
| Synonym: |
|
| GI: |
127199 |
| Orf: |
|
| COG: |
COG0030 |
| UniProt: |
P10738 |
| Structures: |
|
|
|
| Complex: |
|
| Enzyme type: |
methyltransferase |
| Position of modification - modification: |
l:2058(2058) - m6A
|
Comments:
ErmBC methylates the exocyclic amine of A2058 in Peptidyl Center (between helix 73 and 74) of 23S rRNA. It is responsible for the development of bacterial resistance to lincosamide/ Streptogramin-type of antibiotics. This enzyme arosed in E. coli by lateral gene transfer from a gram positive bacteria.
Protein sequence:
MNKNIKYSQNFLTSEKVLNQIIKQLNLKETDTVYEIGTGKGHLTTKLAKISKQVTSIELDSHLFNLSSEKLKSNTRVTLIHQDILQFQFPNKQRYKIVGN
IPYHLSTQIIKKVVFESHASDIYLIVEEGFYKRTLDIHRTLGLLLHTQVSIQQLLKLPAECFHPKPRVNSVLIKLTRHTTDVPDKYWKLYTYFVSKWVNR
EYRQLFTKNQFHQAMKHAKVNNLSTVTYEQVLSIFNSYLLFNGRK
Enzymatic activities:
| Reaction
| Substrate
| Type
| Position
|
|
A:m6A
|
rRNA (r) |
LSU/23S/prokaryotic cytosol |
2058 |
Publications:
| Title |
Authors |
Journal |
Details |
PubMed Id |
DOI |
| Evidence for natural gene transfer from gram-positive cocci to Escherichia coli. |
Brisson-Noel A, Arthur M, Courvalin P |
J Bacteriol |
[details]
|
2832378
|
-
|
Links:
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