ID Card:
Protein sequence:
MGEKRNRNGKDANSQNRKKFKVSSGFLDPGTSGIYATCSRRHERQAAQELQLLFEEKFQELYGDIKEGEDESENDEKKDLSIEDQIKKELQELKGEETGKDLSSGETKKKDPLAFIDLNCECVTFCKTRKPIVPEEFVLSIMKDLADPKNMVKRTRYVQKLTPITYSCNAKMEQLIKLANLVIGPHFHDPSNVKKNYKFAVEVTRRNFNTIERMDIINQVVKLVNKEGSEFNHTVDLKNYDKLILVECFKSNIGMCVVDGDYKTKYRKYNVQQLYESKFRKDEDKSVKQ
Comments:
TAN1 is required for formation of ac4C12 in leucine and serine tRNAs. TAN1 interacts in vivo in yeast cells with RRA1 (KRE33), and, on this basis, was suggested to work as a tRNA adaptor to Kre33, which is a demonstrated catalytically active acetyltransferase. The human homolog of TAN1 is THUMPD1. THUMPD1 interacts in vivo with NAT10, the human homolog of KRE33.
Alpha Fold Predicted Structure:
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Protein sequence:
M
G
E
K
R
N
R
N
G
K
D
A
N
S
Q
N
R
K
K
F
K
V
S
S
G
F
L
D
P
G
T
S
G
I
Y
A
T
C
S
R
R
H
E
R
Q
A
A
Q
E
L
Q
L
L
F
E
E
K
F
Q
E
L
Y
G
D
I
K
E
G
E
D
E
S
E
N
D
E
K
K
D
L
S
I
E
D
Q
I
K
K
E
L
Q
E
L
K
G
E
E
T
G
K
D
L
S
S
G
E
T
K
K
K
D
P
L
A
F
I
D
L
N
C
E
C
V
T
F
C
K
T
R
K
P
I
V
P
E
E
F
V
L
S
I
M
K
D
L
A
D
P
K
N
M
V
K
R
T
R
Y
V
Q
K
L
T
P
I
T
Y
S
C
N
A
K
M
E
Q
L
I
K
L
A
N
L
V
I
G
P
H
F
H
D
P
S
N
V
K
K
N
Y
K
F
A
V
E
V
T
R
R
N
F
N
T
I
E
R
M
D
I
I
N
Q
V
V
K
L
V
N
K
E
G
S
E
F
N
H
T
V
D
L
K
N
Y
D
K
L
I
L
V
E
C
F
K
S
N
I
G
M
C
V
V
D
G
D
Y
K
T
K
Y
R
K
Y
N
V
Q
Q
L
Y
E
S
K
F
R
K
D
E
D
K
S
V
K
Q
Secondary Structure Alphabet
G: 3-turn helix (310 helix) H: α-helix I: 𝝅-helix (5 - turn helix) T: Hydrogen Bonded Turn B: β-sheet S: Bend C: Coil (residues not present in any of the above conformations) N: Not assigned
Download PDB Structures & DSSP Secondary Structures:
Publications:
Title
Authors
Journal
Details
PubMed Id DOI
The Saccharomyces cerevisiae TAN1 gene is required for N4-acetylcytidine formation in tRNA.
Johansson MJ, Bystrom AS
RNA
[details]
15037780
-
Yeast Kre33 and human NAT10 are conserved 18S rRNA cytosine acetyltransferases that modify tRNAs assisted by the adaptor Tan1/THUMPD1.
Sharma S, Langhendries JL, Watzinger P, Kotter P, Entian KD, Lafontaine DL...
Nucleic Acids Res
[details]
25653167
-
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