Modomics - A Database of RNA Modifications

ID Card:

Full name: preQ1 synthase
Synonym: YgcD
GI: 2495654
Orf: yqcD, b2794
COG: COG2904
UniProt: Q46920
Alpha Fold Predicted Structure: AF-Q46920-F1
Enzyme type: oxidoreductase
Position of modification - modification: t:34 - Q



Protein sequence:

MSSYANHQALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLLKSNCLITHQPDWGSLQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ

Comments:

Reaction preQ0base:preQ0 does not occur under physiological conditions, because normally all preQ0(b) is converted to preQ1(b) by QueF.




Reaction Substrate SubstrateType Position (Anti)Codon Modified (Anti)Codon Amino Acid Change Transcript Name Transcript Region Cellular Localization References
preQ0base:preQ1base    

Alpha Fold Predicted Structure:






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Protein sequence:

M S S Y A N H Q A L A G L T L G K S T D Y R D T Y D A S L L Q G V P R S L N R D P L G L K A D N L P F H G T D I W T L Y E L S W L N A K G L P Q V A V G H V E L D Y T S V N L I E S K S F K L Y L N S F N Q T R F N N W D E V R Q T L E R D L S T C A Q G K I S V A L Y R L D E L E G Q P I G H F N G T C I D D Q D I T I D N Y E F T T D Y L E N A T C G E K V V E E T L V S H L L K S N C L I T H Q P D W G S L Q I Q Y R G R Q I D R E K L L R Y L V S F R H H N E F H E Q C V E R I F N D L L R F C Q P E K L S V Y A R Y T R R G G L D I N P W R S N S D F V P S T T R L V R Q

Secondary Structure Alphabet

  • G: 3-turn helix (310helix)
  • H: α-helix
  • I: 𝝅-helix (5 - turn helix)
  • T: Hydrogen Bonded Turn
  • B: β-sheet
  • S: Bend
  • C: Coil (residues not present in any of the above conformations)
  • N: Not assigned

Download PDB Structures & DSSP Secondary Structures:

Alpha Fold Pdb Files   AF-Q46920-F1.pdb  
Alpha Fold Pdbx/mmCIF Files   AF-Q46920-F1.cif  
DSSP Secondary Structures   Q46920.dssp  





Publications:

Title Authors Journal Details PubMed Id DOI
From cyclohydrolase to oxidoreductase: discovery of nitrile reductase activity in a common fold. Van Lanen SG, Reader JS, Swairjo MA, de Crecy-Lagard V, Lee B, Iwata-Reuyl D Proc Natl Acad Sci U S A [details] 15767583 -
Identification of four genes necessary for biosynthesis of the modified nucleoside queuosine. Reader JS, Metzgar D, Schimmel P, de Crecy-Lagard V J Biol Chem [details] 14660578 -

Links:

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