Modomics - A Database of RNA Modifications

Full name:	preQ1 synthase
Synonym:	YgcD
GI:	2495654
Orf:	yqcD, b2794
COG:	COG2904
UniProt:	Q46920
Structures:	\| \|
Complex:
Enzyme type:	oxidoreductase
Position of modification - modification:	t:34 - Q

Comments:

Reaction preQ0base:preQ0 does not occur under physiological conditions, because normally all preQ0(b) is converted to preQ1(b) by QueF.

Protein sequence:

MSSYANHQALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSF
NQTRFNNWDEVRQTLERDLSTCAQGKISVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLLKSNCLITHQPDWGS
LQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ

Enzymatic activities:

Reaction	Substrate	Type	Position
preQ0base:preQ1base			None

Publications:

Title	Authors	Journal	Details	PubMed Id	DOI
From cyclohydrolase to oxidoreductase: discovery of nitrile reductase activity in a common fold.	Van Lanen SG, Reader JS, Swairjo MA, de Crecy-Lagard V, Lee B, Iwata-Reuyl D	Proc Natl Acad Sci U S A	[details]	15767583	-
Identification of four genes necessary for biosynthesis of the modified nucleoside queuosine.	Reader JS, Metzgar D, Schimmel P, de Crecy-Lagard V	J Biol Chem	[details]	14660578	-

Links:

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