Modomics - A Database of RNA Modifications

ID Card:

Full name: Cysteine desulfurase, mitochondrial
Synonym: Spl1
GI: 45644965
Orf: YCL017C
COG: COG1104
UniProt: P25374
Alpha Fold Predicted Structure: AF-P25374-F1
Enzyme type: cysteine desulfurase



Protein sequence:

MLKSTATRSITRLSQVYNVPAATYRACLVSRRFYSPPAAGVKLDDNFSLETHTDIQAAAKAQASARASASGTTPDAVVASGSTAMSHAYQENTGFGTRPIYLDMQATTPTDPRVLDTMLKFYTGLYGNPHSNTHSYGWETNTAVENARAHVAKMINADPKEIIFTSGATESNNMVLKGVPRFYKKTKKHIITTRTEHKCVLEAARAMMKEGFEVTFLNVDDQGLIDLKELEDAIRPDTCLVSVMAVNNEIGVIQPIKEIGAICRKNKIYFHTDAAQAYGKIHIDVNEMNIDLLSISSHKIYGPKGIGAIYVRRRPRVRLEPLLSGGGQERGLRSGTLAPPLVAGFGEAARLMKKEFDNDQAHIKRLSDKLVKGLLSAEHTTLNGSPDHRYPGCVNVSFAYVEGESLLMALRDIALSSGSACTSASLEPSYVLHALGKDDALAHSSIRFGIGRFSTEEEVDYVVKAVSDRVKFLRELSPLWEMVQEGIDLNSIKWSGH

Comments:

Nfs1 is the eukaryal ortholog of bacterial IscS. This sulfur donor protein contains a pyridoxal phosphate cofactor and is involved in the formation of s2U at position 34 of anticodon in both cytoplasmic and mitochondrial tRNAs. In mitochondria, it forms a strong complex with Lsd11p. In the cytoplasm, the subsequent sulphur cascade relay system is very different from the one in mitochondria (see Urm1, Uba4 and Tum1).





Alpha Fold Predicted Structure:






Clear Selection and Reset Camera

Protein sequence:

M L K S T A T R S I T R L S Q V Y N V P A A T Y R A C L V S R R F Y S P P A A G V K L D D N F S L E T H T D I Q A A A K A Q A S A R A S A S G T T P D A V V A S G S T A M S H A Y Q E N T G F G T R P I Y L D M Q A T T P T D P R V L D T M L K F Y T G L Y G N P H S N T H S Y G W E T N T A V E N A R A H V A K M I N A D P K E I I F T S G A T E S N N M V L K G V P R F Y K K T K K H I I T T R T E H K C V L E A A R A M M K E G F E V T F L N V D D Q G L I D L K E L E D A I R P D T C L V S V M A V N N E I G V I Q P I K E I G A I C R K N K I Y F H T D A A Q A Y G K I H I D V N E M N I D L L S I S S H K I Y G P K G I G A I Y V R R R P R V R L E P L L S G G G Q E R G L R S G T L A P P L V A G F G E A A R L M K K E F D N D Q A H I K R L S D K L V K G L L S A E H T T L N G S P D H R Y P G C V N V S F A Y V E G E S L L M A L R D I A L S S G S A C T S A S L E P S Y V L H A L G K D D A L A H S S I R F G I G R F S T E E E V D Y V V K A V S D R V K F L R E L S P L W E M V Q E G I D L N S I K W S G H
50100150200250300350400450SequenceGHTBSN

Secondary Structure Alphabet

  • G: 3-turn helix (310helix)
  • H: α-helix
  • I: 𝝅-helix (5 - turn helix)
  • T: Hydrogen Bonded Turn
  • B: β-sheet
  • S: Bend
  • C: Coil (residues not present in any of the above conformations)
  • N: Not assigned

Download PDB Structures & DSSP Secondary Structures:

Alpha Fold Pdb Files   AF-P25374-F1.pdb  
Alpha Fold Pdbx/mmCIF Files   AF-P25374-F1.cif  
DSSP Secondary Structures   P25374.dssp  





Publications:

Links:

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