Modomics - A Database of RNA Modifications

Full name:	tRNA (uridine-O(2)-)-methyltransferase
Synonym:
GI:	6325227
Orf:	YPL030w
COG:	COG2227
UniProt:	Q02648
Structures:	\| \|
Complex:
Enzyme type:	methyltransferase
Position of modification - modification:	t:44 - Um

Comments:

Protein sequence:

MTGDGSAHISKNNQNQHKDRFKFIVNDKSILGPQWLSLYQTDGKVTFAKSHFEQAMMNVIREPNINSTVILRADILKEINHAAEAGSEPKFDESVLKKFE
IDNGNESGEEDVKKINIEDLNIRSCETSESLKLSPVHEFVRRIIPRNFYKDAIINQTCLILNSKDPNFQETSLIVYTPHINSEKDCPFYIPRTQSVGILL
HQSVLSVHYIPFPEDKTAFTDESERVVRTAYRLLQTANKHSKGVMQGYEKRVNHDQVVNKVNFQNTYIVLKKKYSKFLVENWAESTDPKKHVFEDIAIAA
FLIELWIKVYGPDFRSKMQFRDLGCGNGALCYILLSESIKGLGIDARKRKSWSIYPPEVQSSLKEQVIIPSILLRPHPALKRQVPHLEHNGRFFPVKVTH
EVIAPATVVYSSEDLLKSPQVNTAEFPPDTFIIGNHSDELTCWIPLLGHPYMVIPCCSHNFSGQRVRFNVRKRSPRSNEIKNQNNSKSTYSGLVDHVEYI
SSRVGWKVEKEMLRIPSTRNAAIIGVENATLKHFPTQAVYDMIWEDGGAEGWIQNTMSLLKRNPRNH

Enzymatic activities:

Reaction	Substrate	Type	Position
U:Um	tRNA (t)		44

Publications:

Title	Authors	Journal	Details	PubMed Id	DOI
Identification of yeast tRNA Um(44) 2'-O-methyltransferase (Trm44) and demonstration of a Trm44 role in sustaining levels of specific tRNA(Ser) species.	Kotelawala L, Grayhack EJ, Phizicky EM	RNA	[details]	18025252	-