| Full name: |
Mitochondrial translation optimization protein 1 |
| Synonym: |
Ips1 |
| GI: |
115502421 |
| Orf: |
YGL236C |
| COG: |
COG0445 |
| UniProt: |
P53070 |
| Structures: |
|
|
|
| Complex: |
Mto1/Mss1 |
| Enzyme type: |
other |
| Position of modification - modification: |
t:34 - cmnm5s2U
|
Comments:
Yeast mitochondrial homolog of bacterial MnmG (GidA). Favoprotein. Makes a stable complex with Mss1p. Does not work on cytoplasmic tRNAs. Belongs to the bacterial gidA family but is distinct from bacterial Gid, renamed TrmFO.
Protein sequence:
MLRVTTLASSCTSFPLQVLRRRLTISSLTSFQPTTKTQVVVIGAGHAGCEAAAASSRTGAHTTLITPSLT
DIGKCSCNPSIGGVGKGILVKEIDALDGLMGKVTDLAGVQFKMLNRSKGPAVWGPRAQIDRELYKKYMQR
ELSDKKAHPNLSLLQNKVADLILYDPGCGHKVIKGVVLDDGTQVGADQVIITTGTFLSAEIHIGDKRIAA
GRIGEQPTYGISNTLQNEVGFQLGRLKTGTPARLAKESIDFSALEVQKGDALPVPMSFLNETVSVEPTKQ
LDCFGTHTTPQMHDFLRNNLHQSIHIQDTTIKGPRYCPSIEAKILRFPDRSSHKIWLEPEGFNSDVIYPN
GISNSMPEDVQLQMMRLIPGMANVEILQPAYGVEYDYVDPRQLKPSLETKLVDGLFLAGQINGTTGYEEA
AAQGIIAGINAGLLSRQEREQLVLKRSEAYIGVLIDDLINNGVIEPYRMFTSRSEFRISVRADNADFRLT
PIGAQLGIISPVRLSQYSRDKHLYDETIRALQNFKLSSQKWSSLLQANIAPQAENRSAWEIFRFKDMDLH
KLYECIPDLPINLLDIPMHVVTKINIQGKYEPYIVKQNQFVKAFQADENMLLPQDYDYRQLPTLSTECKL
LLNRVQPLTIGQARRIQGITAAALFELYRVARKPSQPVM
Enzymatic activities:
| Reaction
| Substrate
| Type
| Position
|
|
s2U:cmnm5s2U
|
tRNA (t) |
Leu/UAA/mitochondrial |
34 |
|
U:cmnm5U
|
tRNA (t) |
|
34 |
Publications:
| Title |
Authors |
Journal |
Details |
PubMed Id |
DOI |
| MTO1 codes for a mitochondrial protein required for respiration in paromomycin-resistant mutants of Saccharomyces cerevisiae. |
Colby G, Wu M, Tzagoloff A |
J Biol Chem |
[details]
|
9774408
|
-
|
| Mitochondria-specific RNA-modifying enzymes responsible for the biosynthesis of the wobble base in mitochondrial tRNAs. Implications for the molecular pathogenesis of human mitochondrial diseases. |
Umeda N, Suzuki T, Yukawa M, Ohya Y, Shindo H, Watanabe K, Suzuki T |
J Biol Chem |
[details]
|
15509579
|
-
|
Links: