RsmG is an AdoMet-dependent methyltransferase responsible for the synthesis of m7G527 in the universally conserved loop of hairpin 18 in domain I of bacterial 16S rRNA. Deletion of rsmG gene conferred high-level resistance to the aminoglycoside antibiotics streptomycin and neomycin in Salmonella.
Mutations in rsmG, encoding a 16S rRNA methyltransferase, result in low-level streptomycin resistance and antibiotic overproduction in Streptomyces coelicolor A3(2).
Nishimura K, Hosaka T, Tokuyama S, Okamoto S, Ochi K
Deletion of gene encoding methyltransferase (gidB) confers high-level antimicrobial resistance in Salmonella.
Mutations in rsmG, encoding a 16S rRNA methyltransferase, result in low-level streptomycin resistance and antibiotic overproduction in Streptomyces coelicolor A3(2).
Regulation of expression and catalytic activity of Escherichia coli RsmG methyltransferase.