RsmG from Escherichia coli - protein summary.
Ribosomal RNA small subunit methyltransferase G
Position of modification - modification:
s:527(527) - m7G
RsmG is an AdoMet-dependent methyltransferase responsible for the synthesis of m7G527 in the universally conserved loop of hairpin 18 in domain I of bacterial 16S rRNA. Deletion of rsmG gene conferred high-level resistance to the aminoglycoside antibiotics streptomycin and neomycin in Salmonella.
Mutations in rsmG, encoding a 16S rRNA methyltransferase, result in low-level streptomycin resistance and antibiotic overproduction in Streptomyces coelicolor A3(2).
Nishimura K, Hosaka T, Tokuyama S, Okamoto S, Ochi K
Regulation of expression and catalytic activity of Escherichia coli RsmG methyltransferase.
Benitez-Paez A, Villarroya M, Armengod ME
Deletion of gene encoding methyltransferase (gidB) confers high-level antimicrobial resistance in Salmonella.
Mikheil DM, Shippy DC, Eakley NM, Okwumabua OE, Fadl AA
J Antibiot (Tokyo)
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