ID Card:
Full name:
tRNA(His) guanylyltransferase
GI:
45270428
Orf:
YGR024c
COG:
COG4021
UniProt:
P53215
Structures:
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Alpha Fold Predicted Structure:
AF-P53215-F1
Enzyme type:
guanylyltransferase
Position of modification - modification:
t :0 - G
Protein sequence:
MANSKFGYVRQFETHDVILPQCYIVVRIDGKKFHEFSKFYEFAKPNDENALKLMNACAKNLVLKYKNDIILAFGESDEYSFILKSSTTLFNRRKDKLATLFGSFFTSNYVALWAKFFPEKPLNIKHLPYFDSRCVAYPNLQTIKDYLSWRYVDTHINNLYNTTFWQLIIKCGLTPQESEKKLCGTFSNEKQEILFSECGINYNNEPEMFKKGSLVTRKGEILHINVIAQIDELFEGY
Comments:
tRNAHis guanylyltransferase, adds a guanosine residue to the 5' end of tRNAHis after transcription and RNase P cleavage. Enzymes from Thg1 family exhibit 3'-to-5' polymerase activity. A crystal structure of Mycobacterium tuberculosis and H. sapiens homologues have been solved (3OTB, 3OTD, 3OTE and 3OTC, respectively).
Alpha Fold Predicted Structure:
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Protein sequence:
M
A
N
S
K
F
G
Y
V
R
Q
F
E
T
H
D
V
I
L
P
Q
C
Y
I
V
V
R
I
D
G
K
K
F
H
E
F
S
K
F
Y
E
F
A
K
P
N
D
E
N
A
L
K
L
M
N
A
C
A
K
N
L
V
L
K
Y
K
N
D
I
I
L
A
F
G
E
S
D
E
Y
S
F
I
L
K
S
S
T
T
L
F
N
R
R
K
D
K
L
A
T
L
F
G
S
F
F
T
S
N
Y
V
A
L
W
A
K
F
F
P
E
K
P
L
N
I
K
H
L
P
Y
F
D
S
R
C
V
A
Y
P
N
L
Q
T
I
K
D
Y
L
S
W
R
Y
V
D
T
H
I
N
N
L
Y
N
T
T
F
W
Q
L
I
I
K
C
G
L
T
P
Q
E
S
E
K
K
L
C
G
T
F
S
N
E
K
Q
E
I
L
F
S
E
C
G
I
N
Y
N
N
E
P
E
M
F
K
K
G
S
L
V
T
R
K
G
E
I
L
H
I
N
V
I
A
Q
I
D
E
L
F
E
G
Y
20 40 60 80 100 120 140 160 180 200 220 Sequence G H T B S N
Secondary Structure Alphabet
G: 3-turn helix (310 helix) H: α-helix I: 𝝅-helix (5 - turn helix) T: Hydrogen Bonded Turn B: β-sheet S: Bend C: Coil (residues not present in any of the above conformations) N: Not assigned
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