Full name: tRNA wybutosine-synthesizing protein 3
Synonym: YGL050W
GI: 1322543
Orf:
COG: COG1590
UniProt: P53177
Structures: | |
Complex:
Enzyme type: methyltransferase
Position of modification - modification: t:37 - yW

Comments:

TYW3 takes part in wyosine synthesis. It methylates N-4 position of yW-86 in Ado-Met-dependent manner to yield yW-72.

Protein sequence:

MAAQNAFEQKKRAILNEIDSTQPDLSPKGTIDELCLPIIDLINASADMVTTSSCSGRVSVFLEGTKSYNG EVKIGGKGQGGKWLYVTHDREKVIGWLDELKSKSEFSFELSGKEIPTEKVTGSIRYILYKYEPFILHVKC RDFQAASKLYNTAMSCGFRESGIGSNNLVAIRINIKLDVPLGYLDETSGTLKFFVTPEYVSVLDSLSLSK FDENTRKMQALYDRIEKELINCAPDVNSKVNITPIETKEERRERKKREGMERQRQLKSPQNVL

Enzymatic activities:

Reaction Substrate Type Position
yW-86:yW-72 tRNA (t) Phe/#AA/cytosolic 37
yW-86:yW-72 tRNA (t) Phe/#AA/cytosolic 37

Publications:

Title Authors Journal Details PubMed Id DOI
Biosynthesis of wybutosine, a hyper-modified nucleoside in eukaryotic phenylalanine tRNA. Noma A, Kirino Y, Ikeuchi Y, Suzuki T EMBO J [details] 16642040 -

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