NHP2L1 from Homo sapiens - protein summary.
NHP2L1 (15.5kD) protein is a homologue of yeast Snu13 and Archaea L7Ae. Binds to a common kink-turn motif of snoRNA and U4/U6, U5 splicesomal snRNA. Belongs to C/D RNP complexes acting on pre-rRNA, pre-mRNA, snRNA and a few intron-containing tRNA.
Crystal structure of the spliceosomal 15.5kD protein bound to a U4 snRNA fragment.
Vidovic I, Nottrott S, Hartmuth K, Luhrmann R, Ficner R
Binding of the human Prp31 Nop domain to a composite RNA-protein platform in U4 snRNP.
Liu S, Li P, Dybkov O, Nottrott S, Hartmuth K, Luhrmann R, Carlomagno T, Wahl MC
Functional interaction of a novel 15.5kD [U4/U6.U5] tri-snRNP protein with the 5' stem-loop of U4 snRNA.
Nottrott S, Hartmuth K, Fabrizio P, Urlaub H, Vidovic I, Ficner R, Luhrmann R
Cloning and mapping of a human novel cDNA (NHP2L1) that encodes a protein highly homologous to yeast nuclear protein NHP2.
Saito H, Fujiwara T, Shin S, Okui K, Nakamura Y...
Cytogenet Cell Genet
Biogenesis and intranuclear trafficking of human box C/D and H/ACA RNPs.
Kiss T, Fayet E, Jady BE, Richard P, Weber M...
Cold Spring Harb Symp Quant Biol
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