Full name: tRNA 2-thiouridine(34) synthase
Synonym: yheM
GI: 16131223
Orf:
COG: COG2923
UniProt: P45531
Structures: | 2D1P |
Complex: TusBCD

Comments:

Part of a TusBCD complex which functions as a heterohexamer (a dimer of the heterotrimer). TusBCD complex participates in sulfur transfer from IscS cystein desulfurase to MnmA protein which participates in mnm5s2U synthesis at tRNA wobble positions. It mediates sulfur relay via a putative persulfide state of the TusD subunit. It transfers sulfur from TusA to TusE.

Protein sequence:

MKRIAFVFSTAPHGTAAGREGLDALLATSALTDDLAVFFIADGVFQLLPGQKPDAVLARDYIATFKLLGL YDIEQCWVCAASLRERGLDPQTPFVVEATPLEADALRRELANYDVILRF

Publications:

Title Authors Journal Details PubMed Id DOI
Mechanistic insights into sulfur relay by multiple sulfur mediators involved in thiouridine biosynthesis at tRNA wobble positions. Ikeuchi Y, Shigi N, Kato J, Nishimura A, Suzuki T Mol Cell [details] 16387657 -
Structural basis for sulfur relay to RNA mediated by heterohexameric TusBCD complex. Numata T, Fukai S, Ikeuchi Y, Suzuki T, Nureki O Structure [details] 16472754 -

Links:

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