ID Card:
Full name:
tRNA 2-thiouridine synthesizing protein E
Synonym:
yccK
GI:
90111197
COG:
COG2920
UniProt:
P0AB18
Structures:
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Alpha Fold Predicted Structure:
AF-P0AB18-F1
Enzyme type:
sulfurtransferase
Protein sequence:
MLIFEGKEIETDTEGYLKESSQWSEPLAVVIAENEGISLSPEHWEVVRFVRDFYLEFNTSPAIRMLVKAMANKFGEEKGNSRYLYRLFPKGPAKQATKIAGLPKPVKCI
Comments:
TusE binds TusBCD complex and stimulates sulfur transfer from TusA to TusD. TusE also interacts with a MnmA-tRNA complex. It is necessary for sulfur transfer from IscS cysteine desulfurase to MnmA protein which participates in mnm5s2U synthesis at tRNA wobble positions.
Alpha Fold Predicted Structure:
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Protein sequence:
M
L
I
F
E
G
K
E
I
E
T
D
T
E
G
Y
L
K
E
S
S
Q
W
S
E
P
L
A
V
V
I
A
E
N
E
G
I
S
L
S
P
E
H
W
E
V
V
R
F
V
R
D
F
Y
L
E
F
N
T
S
P
A
I
R
M
L
V
K
A
M
A
N
K
F
G
E
E
K
G
N
S
R
Y
L
Y
R
L
F
P
K
G
P
A
K
Q
A
T
K
I
A
G
L
P
K
P
V
K
C
I
Secondary Structure Alphabet
G: 3-turn helix (310 helix) H: α-helix I: 𝝅-helix (5 - turn helix) T: Hydrogen Bonded Turn B: β-sheet S: Bend C: Coil (residues not present in any of the above conformations) N: Not assigned
Download PDB Structures & DSSP Secondary Structures:
Publications:
Title
Authors
Journal
Details
PubMed Id DOI
Mechanistic insights into sulfur relay by multiple sulfur mediators involved in thiouridine biosynthesis at tRNA wobble positions.
Ikeuchi Y, Shigi N, Kato J, Nishimura A, Suzuki T
Mol Cell
[details]
16387657
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Links: