TrmY from Haloferax volcanii - protein summary.
Position of modification - modification:
t:54 - m1Y
AdoMet dependent methyltransferase. Pseudouridine in position 55 is important for efficient conversion of Psi54 to m1Psi54. This modification is located in the T-loop and is important for the tertiary structure of the tRNA molecule. Crystal structure of TrmY from M. jannaschii was solved at 1.4 and 1.55A resolution (see the entry for M. jannaschii TrmY).
The archaeal COG1901/DUF358 SPOUT-methyltransferase members, together with pseudouridine synthase Pus10, catalyze the formation of 1-methylpseudouridine at position 54 of tRNA.
Chatterjee K, Blaby IK, Thiaville PC, Majumder M, Grosjean H, Yuan YA, Gupta R, de Crécy-Lagard V
Identification of the enzyme responsible for N1-methylation of pseudouridine 54 in archaeal tRNAs.
Wurm JP, Griese M, Bahr U, Held M, Heckel A, Karas M, Soppa J, Wöhnert J
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