TrmY from Methanocaldococcus jannaschii - protein summary.
Position of modification - modification:
t:54 - m1Y
AdoMet dependent methyltransferase. It was shown to catalyze Y:m1Y reaction in vitro in position 54 of a synthetic substrate resembling tRNATrp. Requires pseudouridine (or possibly uridine) in position 55 for efficient conversion of Y54 to m1Y54. This modification is located in the T-loop and is important for the tertiary structure of the tRNA molecule.
The archaeal COG1901/DUF358 SPOUT-methyltransferase members, together with pseudouridine synthase Pus10, catalyze the formation of 1-methylpseudouridine at position 54 of tRNA.
Chatterjee K, Blaby IK, Thiaville PC, Majumder M, Grosjean H, Yuan YA, Gupta R, de Crécy-Lagard V
Identification of the enzyme responsible for N1-methylation of pseudouridine 54 in archaeal tRNAs.
Wurm JP, Griese M, Bahr U, Held M, Heckel A, Karas M, Soppa J, Wöhnert J
Crystal structure of Mj1640/DUF358 protein reveals a putative SPOUT-class RNA methyltransferase.
Chen HY, Yuan YA
J Mol Cell Biol
Copyright © Genesilico - All rights reserved
If you have any advice or suggestions for corrections or improvements, please contact: