RlmA(I) from Escherichia coli - protein summary.
Ribosomal RNA large subunit methyltransferase A
Position of modification - modification:
l:745(745) - m1G
RlmAI is found only in gram negative bacteria. The enzyme is dimeric and catalyzes the formation of m1G at position 745, in the loop of helix 35 of domain II of the large subunit rRNA. It has a zinc domain and binds two molecules of AdoMet. RlmAI is the ortholog of RlmAII that is found only in certain gram positive bacteria (like Steptococcus).
Identification of the rrmA gene encoding the 23S rRNA m1G745 methyltransferase in Escherichia coli and characterization of an m1G745-deficient mutant.
Gustafsson C, Persson BC
Crystal structure of RlmAI: implications for understanding the 23S rRNA G745/G748-methylation at the macrolide antibiotic-binding site.
Das K, Acton T, Chiang Y, Shih L, Arnold E, Montelione GT
Proc Natl Acad Sci U S A
Methylation of 23S rRNA nucleotide G745 is a secondary function of the RlmAI methyltransferase.
Liu M, Novotny GW, Douthwaite S
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