Modomics - A Database of RNA Modifications

Full name:	tRNA (guanine(37)-N1)-methyltransferase Trm5b
Synonym:	MJ0883
GI:	15669073
Orf:
COG:	COG2520
UniProt:	Q58293
Structures:	\| 2ZZM \| 2ZZN \| 3AY0 \| 2YX1 \|
Complex:
Enzyme type:	methyltransferase
Position of modification - modification:	t:37 - m1G

Comments:

Protein sequence:

MPLCLKINKKHGEQTRRILIENNLLNKDYKITSEGNYLYLPIKDVDEDILKSILNIEFELVDKELEEKKIIKKPSFREIISKKYRKEIDEGLISLSYDVV
GDLVILQISDEVDEKIRKEIGELAYKLIPCKGVFRRKSEVKGEFRVRELEHLAGENRTLTIHKENGYRLWVDIAKVYFSPRLGGERARIMKKVSLNDVVV
DMFAGVGPFSIACKNAKKIYAIDINPHAIELLKKNIKLNKLEHKIIPILSDVREVDVKGNRVIMNLPKFAHKFIDKALDIVEEGGVIHYYTIGKDFDKAI
KLFEKKCDCEVLEKRIVKSYAPREYILALDFKINKK

Enzymatic activities:

Reaction	Substrate	Type	Position
G:m1G	tRNA (t)	Cys/GCA/prokaryotic cytosol	37
G:m1G	tRNA (t)	Leu/UAG/prokaryotic cytosol	37

Publications:

Title	Authors	Journal	Details	PubMed Id	DOI
Mechanism of N-methylation by the tRNA m1G37 methyltransferase Trm5.	Christian T, Lahoud G, Liu C, Hoffmann K, Perona JJ, Hou YM	RNA	[details]	20980671	-
Catalysis by the second class of tRNA(m1G37) methyl transferase requires a conserved proline.	Christian T, Evilia C, Hou YM	Biochemistry	[details]	16768442	-
Tertiary structure checkpoint at anticodon loop modification in tRNA functional maturation.	Goto-Ito S, Ito T, Kuratani M, Bessho Y, Yokoyama S	Nat Struct Mol Biol	[details]	19749755	-
Crystal structure of archaeal tRNA(m(1)G37)methyltransferase aTrm5.	Goto-Ito S, Ito T, Ishii R, Muto Y, Bessho Y, Yokoyama S	Proteins	[details]	18384044	-
Conservation of structure and mechanism by Trm5 enzymes.	Christian T, Gamper H, Hou YM...	RNA	[details]	23887145	-

Links:

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