Modomics - A Database of RNA Modifications

ID Card:

Full name: tRNA dimethylallyltransferase, mitochondrial
Synonym: TRIT1, IPT
GI: 31581534
COG: COG0324
UniProt: Q9H3H1
Alpha Fold Predicted Structure: AF-Q9H3H1-F1
Enzyme type: dimethylallyltransferase
Position of modification - modification: t:37 - i6A



Protein sequence:

MASVAAARAVPVGSGLRGLQRTLPLVVILGATGTGKSTLALQLGQRLGGEIVSADSMQVYEGLDIITNKVSAQEQRICRHHMISFVDPLVTNYTVVDFRNRATALIEDIFARDKIPIVVGGTNYYIESLLWKVLVNTKPQEMGTEKVIDRKVELEKEDGLVLHKRLSQVDPEMAAKLHPHDKRKVARSLQVFEETGISHSEFLHRQHTEEGGGPLGGPLKFSNPCILWLHADQAVLDERLDKRVDDMLAAGLLEELRDFHRRYNQKNVSENSQDYQHGIFQSIGFKEFHEYLITEGKCTLETSNQLLKKGIEALKQVTKRYARKQNRWVKNRFLSRPGPIVPPVYGLEVSDVSKWEESVLEPALEIVQSFIQGHKPTATPIKMPYNEAENKRSYHLCDLCDRIIIGDREWAAHIKSKSHLNQLKKRRRLDSDAVNTIESQSVSPDHNKEPKEKGSPGQNDQELKCSV

Comments:

Mod5 catalyzes the transfer the delta2-isopropyl group from dimethylallyl diphosphate to the exocyclic N6 of A36A37-containing tRNA (i6A37 formation). Eukaryotic Mod5 is the ortholog of bacterial MiaA. There are no MiaA/Mod5 homologs in Archaea. Homo sapiens derived gene was shown to complement S. cerevisiae mutant lacking Mod5.





Alpha Fold Predicted Structure:






Clear Selection and Reset Camera

Protein sequence:

M A S V A A A R A V P V G S G L R G L Q R T L P L V V I L G A T G T G K S T L A L Q L G Q R L G G E I V S A D S M Q V Y E G L D I I T N K V S A Q E Q R I C R H H M I S F V D P L V T N Y T V V D F R N R A T A L I E D I F A R D K I P I V V G G T N Y Y I E S L L W K V L V N T K P Q E M G T E K V I D R K V E L E K E D G L V L H K R L S Q V D P E M A A K L H P H D K R K V A R S L Q V F E E T G I S H S E F L H R Q H T E E G G G P L G G P L K F S N P C I L W L H A D Q A V L D E R L D K R V D D M L A A G L L E E L R D F H R R Y N Q K N V S E N S Q D Y Q H G I F Q S I G F K E F H E Y L I T E G K C T L E T S N Q L L K K G I E A L K Q V T K R Y A R K Q N R W V K N R F L S R P G P I V P P V Y G L E V S D V S K W E E S V L E P A L E I V Q S F I Q G H K P T A T P I K M P Y N E A E N K R S Y H L C D L C D R I I I G D R E W A A H I K S K S H L N Q L K K R R R L D S D A V N T I E S Q S V S P D H N K E P K E K G S P G Q N D Q E L K C S V
50100150200250300350400450SequenceGHITBSN

Secondary Structure Alphabet

  • G: 3-turn helix (310helix)
  • H: α-helix
  • I: 𝝅-helix (5 - turn helix)
  • T: Hydrogen Bonded Turn
  • B: β-sheet
  • S: Bend
  • C: Coil (residues not present in any of the above conformations)
  • N: Not assigned

Download PDB Structures & DSSP Secondary Structures:

Alpha Fold Pdb Files   AF-Q9H3H1-F1.pdb  
Alpha Fold Pdbx/mmCIF Files   AF-Q9H3H1-F1.cif  
DSSP Secondary Structures   Q9H3H1.dssp  





Publications:

Links:

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