| Full name: |
tRNA dimethylallyltransferase, mitochondrial |
| Synonym: |
TRIT1, IPT |
| GI: |
31581534 |
| Orf: |
|
| COG: |
COG0324 |
| UniProt: |
Q9H3H1 |
| Structures: |
|
|
|
| Complex: |
|
| Enzyme type: |
dimethylallyltransferase |
| Position of modification - modification: |
t:37 - i6A
|
Comments:
Mod5 catalyzes the transfer the delta2-isopropyl group from dimethylallyl diphosphate to the exocyclic N6 of A36A37-containing tRNA (i6A37 formation). Eukaryotic Mod5 is the ortholog of bacterial MiaA. There are no MiaA/Mod5 homologs in Archaea. Homo sapiens derived gene was shown to complement S. cerevisiae mutant lacking Mod5.
Protein sequence:
MASVAAARAVPVGSGLRGLQRTLPLVVILGATGTGKSTLALQLGQRLGGEIVSADSMQVYEGLDIITNKVSAQEQRICRHHMISFVDPLVTNYTVVDFRN
RATALIEDIFARDKIPIVVGGTNYYIESLLWKVLVNTKPQEMGTEKVIDRKVELEKEDGLVLHKRLSQVDPEMAAKLHPHDKRKVARSLQVFEETGISHS
EFLHRQHTEEGGGPLGGPLKFSNPCILWLHADQAVLDERLDKRVDDMLAAGLLEELRDFHRRYNQKNVSENSQDYQHGIFQSIGFKEFHEYLITEGKCTL
ETSNQLLKKGIEALKQVTKRYARKQNRWVKNRFLSRPGPIVPPVYGLEVSDVSKWEESVLEPALEIVQSFIQGHKPTATPIKMPYNEAENKRSYHLCDLC
DRIIIGDREWAAHIKSKSHLNQLKKRRRLDSDAVNTIESQSVSPDHNKEPKEKGSPGQNDQELKCSV
Enzymatic activities:
| Reaction
| Substrate
| Type
| Position
|
|
A:i6A
|
tRNA (t) |
many/many/mitochondrion |
37 |
Publications:
| Title |
Authors |
Journal |
Details |
PubMed Id |
DOI |
| Cloning of a human tRNA isopentenyl transferase. |
Golovko A, Hjalm G, Sitbon F, Nicander B |
Gene |
[details]
|
11111046
|
-
|
Links:
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